GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UCEC | cis | rs965469 | 1 | rs6051808 | chr20:3350697 | ITPA | chr20:3190056-3204504:+ | -0.41 | -4.47 | 1.52E-5 | IFN-related cytopenia |
| UCEC | cis | rs965469 | 1 | rs6051809 | chr20:3352551 | ITPA | chr20:3190056-3204504:+ | -0.41 | -4.47 | 1.52E-5 | IFN-related cytopenia |
| UCEC | cis | rs965469 | 1 | rs6051810 | chr20:3355384 | ITPA | chr20:3190056-3204504:+ | -0.41 | -4.47 | 1.52E-5 | IFN-related cytopenia |
| UCEC | cis | rs965469 | 1 | rs6051827 | chr20:3372007 | ITPA | chr20:3190056-3204504:+ | -0.41 | -4.47 | 1.52E-5 | IFN-related cytopenia |
| UCEC | cis | rs965469 | 1 | rs6051831 | chr20:3373712 | ITPA | chr20:3190056-3204504:+ | 0.43 | 4.79 | 3.95E-6 | IFN-related cytopenia |
| UCEC | cis | rs4812048 | 1 | rs6070692 | chr20:57586374 | CTSZ | chr20:57570242-57582309:- | -0.48 | -4.38 | 2.21E-5 | Mean platelet volume |
| UCEC | cis | rs60843830 | 1 | rs60843830 | chr2:286756 | SH3YL1 | chr2:218138-264810:- | -0.43 | -5.85 | 2.98E-8 | Spherical equivalent (joint main effects and education interaction) |
| UCEC | cis | rs9309473 | 1 | rs60844734 | chr2:73623205 | ALMS1P | chr2:73872046-73912692:+ | 0.54 | 6.35 | 2.42E-9 | Metabolite levels |
| UCEC | cis | rs9473555 | 1 | rs60982898 | chr6:49385806 | MUT | chr6:49398994-49431031:- | 0.35 | 5.86 | 2.72E-8 | Folate pathway vitamin levels |
| UCEC | cis | rs965469 | 1 | rs6133036 | chr20:3349682 | ITPA | chr20:3190056-3204504:+ | -0.41 | -4.47 | 1.52E-5 | IFN-related cytopenia |
| UCEC | cis | rs6151429 | 1 | rs6151429 | chr22:51063477 | ARSA | chr22:51063450-51066607:- | -0.93 | -5.92 | 2.11E-8 | Blood metabolite levels |
| UCEC | cis | rs61524473 | 1 | rs61524473 | chr15:45646283 | SLC28A2 | chr15:45544428-45568132:+ | -0.38 | -4.68 | 6.24E-6 | Metabolite levels (small molecules and protein measures) |
| UCEC | cis | rs9815354 | 1 | rs61744385 | chr3:41756986 | ULK4 | chr3:41288091-42003660:- | 0.46 | 5.64 | 8.22E-8 | Diastolic blood pressure |
| UCEC | cis | rs9815354 | 1 | rs61744388 | chr3:41756965 | ULK4 | chr3:41288091-42003660:- | 0.46 | 5.64 | 8.22E-8 | Diastolic blood pressure |
| UCEC | cis | rs950169 | 1 | rs62026530 | chr15:84775840 | LOC388152 | chr15:84867600-84898920:- | -0.47 | -4.83 | 3.25E-6 | Schizophrenia |